I caught the trailer for this flick back when it first came out and didn't feel compelled to see it. It looked like another Judd Apatow/Seth Rogen take on the overgrown baby boy whose self-centered crudely childish behavior is forgiven by everyone because...of whatever the plot device is served up, in this case Rogen's friend getting cancer.
Don't get me wrong, I dug a lot of the movies Apatow and Rogen did together, but their routine seemed to become less and less heartwarming and more and more rim shot reflex forced gags. 50/50 isn't directed or written by Apatow or Rogen, and the latter serves in the capacity of sidekick to Robert Gordon-Levitt whose performance alone is worth the price of admission.
Sometimes he's miscast, but when he isn't he's a delight to watch (500 DAYS OF SUMMER for instance). And in 50/50 his performance gets great support from other performances, like Bryce Dallas Howard's (she almost stole THE HELP) and Anna Kendrick's (who kicked butt in UP IN THE AIR). The rest of the supporting cast are terrific too, including Angelica Houston.
And the story isn't as depressing as the premise seems to forewarn. In fact 50/50 is a terrific little movie that I can highly recommend.